After a short introduction of Nicholas of Lyra’s biographic and intellectual path, I will show how this exegete’s reflection on the Apocalypse is placed within a specific groove according to which the pages of the Book of Revelation provide an opportunity for a continuous reading of the history of Christianity. I will therefore focus mainly on the most problematic moment of the work, namely the au-thor’s comment on Revelation XX. In fact, it is precisely in this chapter that Nicholas, declaring his lack of access to the prophetic gift, reveals his myopia in the face of any attempt to recompose the events surrounding him from an historical-eschatological perspective. As I will show in Part II, with this strategy, the prophetic word is therefore subjected to a speculative work aimed at subtracting it from the claims of the apocalyptic thought and at relocating it adequately within a social project suited to the needs of the Church of the time.