This text is my first attempt to frame theoretically the relation between modern Biotechnology and the historical, epistemological, and normative constitution of Biogerontology, the science responsible for the study of biological ageing. The first part is an attempt to under-stand the cultural placement of modern Biotechnology, for which I resort to Hartmut Rosa’s concept of Verfügbarmachung as a useful tool. The second one departs from the suspect that the possibilities opened by modern Biotechnology might have impacted the main-stream scientific understanding of human ageing, so that I present central biogerontological concepts that might reflect that impact. The relation between Biotechnology’s promise of unleashing life from its biological limitations and Biogerontology’s new understanding of ageing as life-encompassing process of loss of function weaves the text.